Is IV ketamine more effective than ketamine alone for treatment-resistant depression? Is it really important how the medication is administered? Our belief at Cape Town Rehab is that it does, and here’s why.

There are a variety of ways to administer ketamine, as there are with many medications. Some methods, however, offer more advantages than others. Although some physicians might not insist on IV administration, Cape Town Rehab uses a team of professionals that work with IV administration exclusively. Why? It’s because we are perfectionists, committed to making sure you receive the exact dosage for the best results.

Defining Bioavailability: What does it mean? It refers to the actual amount of medication your body can actually use, the active portion that reaches your bloodstream. Ketamine administered via IV is 100% bioavailable, ensuring that the entire dose is absorbed by the body and, more importantly, the brain.

With IV Ketamine, every bit of ketamine you receive reaches your brain precisely where it needs to be, so it is fully effective. By calculating your body weight, and slowly infusing it into your bloodstream, our team of professionals calculate the exact dosage your brain will receive. You are not just taking medication; you are ingesting hope and clarity.

Contrary to intranasal ketamine, intranasal ketamine introduces uncertainty. To prevent drips or running down your throat, the mist must perfectly saturate your mucous membranes. Due to its brief contact with critical brain systems, it’s a bit unreliable, unlike IV infusions that are controlled slowly and precisely.

IM Ketamine: Timing and Side Effects: Knowing how much and how quickly ketamine will reach your bloodstream is a challenge with intramuscular injections. It’s a tricky route, and precision is important when it comes to ketamine. During treatment, side effects become uncontrollable once the medicine is in the muscle, making it less than ideal.

Various routes of bioavailability: Compare their bioavailability:

  • Intravenous: 100%
  • Intramuscular: approximately 93%
  • Intranasal: approximately 45%
  • Sublingual: approximately 19-50% Clear as day, sublingual use with its uncertain range is far from ideal, while IV ketamine ensures solid, safe, and predictable benefits.

Exquisite IV Ketamine: With the ideal low dose precisely measured and administered through IV infusion, you experience all the benefits of ketamine without any interference. Ketamine delivered intravenously is backed by decades of data.

Effectiveness and Controlled Rate: Given through IV, ketamine’s benefits start almost immediately, with a controlled rate ensuring optimal conditions in the brain for sustained relief. The benefits continue to grow as the medication circulates, offering a lifeline when you need it most.

Cape Town Rehab works with a team of professionals that provides you with a low-dose of IV ketamine infusions in a comfortable and clinical in/outpatient setting with medical monitoring and safeguards. Any potential side effects can be instantly addressed, ensuring a smooth experience and a rapid return to daily life.

It is unfortunate that ketamine has been misused for illicit purposes. Cape Town Rehab emphasises the importance of guarding the distribution of ketamine, and our exclusive team of professionals ONLY use IV ketamine infusions minimises the risk of misuse or sharing.

Our team provides ketamine exclusively by IV infusion because we believe that it is the most effective method for providing rapid, maximum benefits in the safest environment possible. Let us help you find the right path for your depression treatment journey. Call us on 0829760806 or email us at


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Sanacora, G., & Katz, R. (2018). Ketamine: A Review for Clinicians. In FOCUS (Vol. 16, Issue 3, pp. 243–250). American Psychiatric Association Publishing. 

Yavi, M., Lee, H., Henter, I. D., Park, L. T., & Zarate, C. A., Jr (2022). Ketamine treatment for depression: a review. Discover mental health, 2(1), 9.

Yip, R., Swainson, J., Khullar, A., McIntyre, R. S., & Skoblenick, K. (2022). Intravenous ketamine for depression: A clinical discussion reconsidering best practices in acute hypertension management. In Frontiers in Psychiatry (Vol. 13). Frontiers Media SA.